Wednesday, August 25, 2010

Drug Discovery: The Evolution of Modern Medicines (A Wiley medical publication) [Hardcover]

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Author: Walter Sneader
ISBN : 9780471904717
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This lively and highly readable survey of the evolution of drugs in medicine and science is written for the nonspecialist. Traces the history of drug discovery, showing how such a diverse range of chemical substances has been introduced into clinical practice.
  • Series: A Wiley medical publication
  • Hardcover: 435 pages
  • Publisher: Wiley; 1 edition (September 13, 1985)
  • Language: English
  • ISBN-10: 0471904716
  • ISBN-13: 978-0471904717
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Drug Discovery: The Evolution of Modern Medicines

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Stage-Wise Adaptive Designs (Wiley Series in Probability and Statistics) [Hardcover]

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Author: Shelemyahu Zacks
ISBN : 9780470050958
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An expert introduction to stage-wise adaptive designs in all areas of statistics

Stage-Wise Adaptive Designs presents the theory and methodology of stage-wise adaptive design across various areas of study within the field of statistics, from sampling surveys and time series analysis to generalized linear models and decision theory. Providing the necessary background material along with illustrative S-PLUS functions, this book serves as a valuable introduction to the problems of adaptive designs.

The author begins with a cohesive introduction to the subject and goes on to concentrate on generalized linear models, followed by stage-wise sampling procedures in sampling surveys. Adaptive forecasting in the area of time series analysis is presented in detail, and two chapters are devoted to applications in clinical trials. Bandits problems are also given a thorough treatment along with sequential detection of change-points, sequential applications in industrial statistics, and software reliability.

S-Plus functions are available to accompany particular computations, and all examples can be worked out using R, which is available on the book's related FTP site. In addition, a detailed appendix outlines the use of these software functions, while an extensive bibliography directs readers to further research on the subject matter.

Assuming only a basic background in statistical topics, Stage-Wise Adaptive Designs is an excellent supplement to statistics courses at the upper-undergraduate and graduate levels. It also serves as a valuable reference for researchers and practitioners in the fields of statistics and biostatistics.

  • Series: Wiley Series in Probability and Statistics (Book 646)
  • Hardcover: 385 pages
  • Publisher: Wiley; 1 edition (April 27, 2009)
  • Language: English
  • ISBN-10: 0470050950
  • ISBN-13: 978-0470050958
  • Product Dimensions: 1 x 6.2 x 9.2 inches
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Stage-Wise Adaptive Designs

Preface.

1 Synopsis.


1.1 Multistage and Sequential Estimation.


1.2 Adaptive Designs for Generalized Linear Models.


1.3 Adaptive Methods for Sampling from Finite Populations.


1.4 Adaptive Prediction and Forecasting in Time Series Analysis.


1.5 Adaptive Search of an MTD in Cancer Phase I Clinical Trials.


1.6 Adaptive and Sequential Procedures in Phase III of Clinical Trials.


1.7 Sequential Allocation of Resources.


1.8 Sequential Detection of Change Points.


1.9 Sequential Methods in Industrial Testing, Reliability, and Design of Experiments.

2 Multistage and Sequential Estimation.


2.1 Stein’s Two-Stage Procedure.


2.2 Modifications to Attain Asymptotic Efficiency.


2.3 Two-Stage Sampling From Exponential Distributions.


2.4 Sequential Fixed-Width Interval Estimation.


2.5 Distributions of Stopping Variables of Sequential Sampling.


2.6 Sequential Fixed-Width Intervals for the Log-Odds in Bernoulli Trials.


2.7 Bayesian Sequential Estimation.

3 Adaptive Designs For Generalized Linear Models.


3.1 Exponential Example.


3.2 Adaptive Designs for the Fisher Information.


3.3 Adaptive Bayesian Designs.


3.4 Adaptive Designs for Inverse Regression.


3.5 Stochastic Approximation.

4 Adaptive Methods for Sampling from Finite Populations.


4.1 Basic Theory.


4.2 Two-Stage and Sequential Estimation of the Population Mean.


4.3 Adaptive Allocation of Stratified SRS.


4.4 Adaptive Search for Special Units.


4.5 Adaptive Estimation of the Size of a Finite Population.


4.6 Applications in Software Reliability.


4.7 Sampling Inspection Schemes.


4.8 Dynamic Bayesian Prediction.

5 Adaptive Prediction and Forecasting in Time Series Analysis.


5.1 Basic Tools of Time Series Analysis.


5.2 Linear Predictors for Covariance Stationary T.S.


5.3 Quadratic LSE Predictors for Nonstationary T.S.


5.4 Moving Averages Predictors for Nonstationary T.S.


5.5 Predictors for General Trends with Exponential Discounting.


5.6 Dynamic Linear Models.


5.7 Asymptotic Behavior of DLM.


5.8 Linear Control of DLM.

6 Adaptive Search of an MTD in Cancer Phase I Clinical Trials.


6.1 Up-And-Down Adaptive Designs.


6.2 Bayesian Adaptive Search: The Continuous Reassessment Method.


6.3 Efficient Dose Escalation with Overdose Control.


6.4 Patient-Specific Dosing.


6.5 Toxicity versus Efficacy.

7 Adaptive and Sequential Procedures in Clinical Trials, Phases II and III.


7.1 Randomization in Clinical Trials.


7.2 Adaptive Randomization Procedures.


7.3 Fixed-Width Sequential Estimation of the Success Probability in Bernoulli Trials.


7.4 Sequential Procedure for Estimating the Probability of Success in Bernoulli Trials.


7.5 Sequential Comparison of Success Probabilities.


7.6 Group Sequential Methods.


7.7 Dynamic Determination of Stage-Wise Samples Size.

8 Sequential Allocation of Resources.


8.1 Bernoulli Bandits.


8.2 Gittins Dynamic Allocation Indices.


8.3 Sequential Allocations in Clinical Trials.


8.4 Bernoulli Bandits with Changepoint.


8.5 Sequential Designs for Estimating the Common Mean of Two Normal Distributions: One Variance Known.

9 Sequential Detection of Changepoints.


9.1 Bayesian Detection When the Distribution Before and After the Change Are Known.


9.2 Bayesian Detection When the Distributions Before and After the Change Are Unknown.


9.3 CUSUM Procedures for Sequential Detection.


9.4 Tracking Algorithms for Processes with Change Points.


9.5 Recursive Estimation with Changepoints.


9.6 Additional Theoretical Contributions.

10 Sequential Methods in Industrial Testing.


10.1 Sequential Testing (SPRT).


10.2 Characteristics of Sequential Procedures in Reliability Estimation and Testing.


10.3 Some Comments on Sequential Design of Experiments.


10.4 Sequential Testing of Software Reliability.


Bibliography.


Appendix: SPLUS/R Programs.


Author Index.


Subject Index.

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Tuesday, August 24, 2010

Plant Molluscicides (A Wiley medical publication) [Paperback]

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ISBN : 9780471912286
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Contains the papers presented at a meeting of the Scientific Working Group on Plant Molluscicides held in Geneva, Switzerland in January of 1983. Reviews throughly, for the first time, the present and potential roles of plant molluscicides, screening methods, problems of evaluation, needs in the field of toxicology, and methods of breeding, selection, and cultivation of plants. This book contains the most complete listing of potential plant molluscicides that is available anywhere. Contributors sum up the state of knowledge in the field and reccommend guidelines for continuing research in new directions.
  • Series: A Wiley medical publication
  • Paperback: 338 pages
  • Publisher: Wiley; 1 edition (November 13, 1987)
  • Language: English
  • ISBN-10: 047191228X
  • ISBN-13: 978-0471912286
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Monday, August 23, 2010

Childhoods in Context (Wiley & OU Childhood) [Paperback]

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ISBN : 9780470846933
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Childhood is a brand new series, co-published with The Open University which represents a coherent and integrated treatment to a wide range of topics and approaches, which will have a relevance to courses in childhood studies; sociology; psychology; anthropology and cultural studies.

The second volume, Childhoods in Context examines the interplay between family, schooling, work, and other influences in the daily lives of children and young people. Topics include changing family patterns, debates about school versus work, and current concerns about child labour. Issues in early childhood are discussed, as well as the transition from child to adult.


? Multi-disciplinary approach
? Multi-cultural perspective
? An interactive text
? Attractive layout and colour design throughout
? A high level of illustration
? Clear and 'student-friendly' style
? Used by the OU for its own teaching
  • Series: Wiley & OU Childhood (Book 3)
  • Paperback: 340 pages
  • Publisher: Wiley; 1 edition (May 6, 2003)
  • Language: English
  • ISBN-10: 0470846933
  • ISBN-13: 978-0470846933
  • Product Dimensions: 0.9 x 7.6 x 9.7 inches
  • Shipping Weight: 2.2 pounds

Childhoods in Context

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Sunday, August 22, 2010

Resolving Marital Conflicts: A Psychodynamic Perspective (Wiley Series on Personality Processes) [Paperback]

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Author: Herbert S. Strean
ISBN : 9780471825043
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Presents a psychodynamic view of marital therapy, covering the dynamics of marital conflict, the therapeutic principles applied in treating that conflict, and the various kinds of neurotic adjustments seen in marital relationships, as well as a brief survey of the history of marriage. Based on the premise that marriage doesn't cause conflicts but only reflects the conflicts characteristic of the individual regardless of marital status, it clarifies the neurotic choices made by a partner exposing more basic psychological problems. Also portrays the process of mate selection as a highly subjective, often irrational process that reflects childhood needs and conflicts. Concludes with a chapter describing the mature spouse.
  • Series: Wiley Series on Personality Processes (Book 112)
  • Paperback: 275 pages
  • Publisher: Wiley-Interscience; 1 edition (October 1985)
  • Language: English
  • ISBN-10: 0471825042
  • ISBN-13: 978-0471825043
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Resolving Marital Conflicts: A Psychodynamic Perspective

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Saturday, August 21, 2010

Essential Medical Genetics, Includes Desktop Edition [Paperback]

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ISBN : 9781405169745
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Adopted at Cambridge University

Essential Medical Genetics provides students, clinicians, counsellors and scientists with the up-to-date information they need regarding the basic principles underlying medical genetics. It also provides guidance on how to apply current knowledge in clinical contexts, covering a wide variety of topics: from genome structure and function to mutations, screening and risk assessment for inherited disorders.

This sixth edition has been substantially updated to include, for instance, the latest information on the Human Genome Project as well as several new molecular genetic and chromosome analysis techniques. In full colour throughout, it includes a number of brand new features, including: a large number of self-assessment questions; 'Essentials' chapter summaries; further reading suggestions; and case study scenarios introducing clinical situations. An invaluable new section gives illustrated practical advice regarding how to choose the best available online genetic databases and also, importantly, how to most easily and most efficiently use them, for a wide range of purposes.

Essential Medical Genetics is the perfect resource for a course on medical genetics, and is now accompanied by a regularly updated website and the FREE enhanced Wiley Desktop Edition (upon purchase of the book).

The companion website at www.wiley.com/go/tobias features figures from the book in PowerPoint format and a link to the authors' website with regularly updated links to genetic databases and additional self-test questions.

  • Paperback: 344 pages
  • Publisher: Wiley-Blackwell; 6 edition (March 21, 2011)
  • Language: English
  • ISBN-10: 1405169745
  • ISBN-13: 978-1405169745
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Essential Medical Genetics, Includes Desktop Edition

I am an OBGYN MFM specialist and this is the best textbook for bringing me current in the field of genetics
By ady davidson
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